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second, it modulates extracellular glutamate and intracellular GSH levels, third, it acts as a reducing agent for protein disulfides and finally it restores thiol pools, which in turn regulate the redox state [7, 53,54,55,56]

Its anti-inflammatory action involves the modulation of key pro-inflammatory cytokines, which are signaling molecules that drive the inflammatory cascade

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GSK-3 is an indispensable positive ferroptosis regulator The above data suggest that GSK-3 is likely a novel positive regulator of ferroptosis

As Joanna Haley, MSTOM, Dipl

Notably, patients with mutations in GGT1 often present with developmental disorders, accumulation of GSH (glutathionaemia and glutathionuria) and reduced circulating levels of cystine 25