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2 O predominantly affect glutamatergic transmission by antagonizing NMDA receptors (NMDARs), causing excitotoxicity, mitochondrial dysfunction, and neuronal apoptosis

This indicates the efficacy of using MET inhibitors alongside ICIs in treating tumors where MET is dysregulated and PD-L1 expression is elevated

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As our understanding of sleep biology continues to evolve, compounds such as DSIP remind us that promising scientific discoveries require careful investigation before they can be translated into safe and effective clinical therapies

There are no FDA-approved peptide drugs for most of the clinical applications prescribers use them for

The combinational effects of N-terminal mutations and C-terminal affinity-enhancing mutations shown in this study remain to be tested for the future study