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doi: 10.3389/fneur.2019.00030 321 StargardtA.SwaabD

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In summary, as conserved cysteine residues are potential candidates for the redox control of proteins due to their ability to undergo reversible oxidation-reduction reactions, participate in enzyme catalysis, maintain structural integrity, and sense the cellular redox environment, Cys190 conservation across different species underscores its essential role in GSAAT enzyme catalysis or its regulatory function ( Supplementary Figure 1 )

This change often leads to genes being silenced as their chromatin structure is less accessible

doi: 10.1016/j.neuroscience.2005.01.059

doi: 10.1007/s12223-016-0449-8 347 RoundtreeM