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This protective response involves up-regulations of the GSH-synthesizing enzyme, GSH-synthetase, the GSH-conjugating enzyme, GST, and the hepatocellular efflux pumps, Mrp2 and Mrp1

Furthermore, we phenotyped Pdgfrb-Cre-Gpt1 flox/flox mice, where ammonia levels were measured to define the correlations with alanine levels, and evaluated liver cancer phenotypes in mouse models induced by diethylnitrosamine injection combined with a choline deficient and high fat diet

Tumour Biol 39:1010428317691429 Lpez de la Oliva AR, Campos-Sandoval JA, Gmez-Garca MC et al (2020) Nuclear translocation of glutaminase GLS2 in human cancer cells associates with proliferation arrest and differentiation

Red Blood Cells: RBCs are non-nucleated cells

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

Although there is a broad clinical spectrum of glutathione synthetase deficiency, manifestations usually include hemolytic anemia, often include metabolic acidosis, and sometimes include progressive neurologic symptoms as well as other systemic signs (eg, respiratory distress, sepsis, hyperbilirubinemia) (62