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If the deficiency was purely dietary, oral supplementation may be considered after initial repletion

This typically reflects a high peptide concentration combined with too little solvent acidity, so the molecules lock into a gel network

There is no evidence that doses above 500mcg produce proportionally better results, and clinical trials using 1mg daily did not dramatically outperform lower doses

However, a significant gray zone exists between 200 and 300 pg/mL where patients may experience symptoms despite levels that appear technically normal

Who Benefits Most from B12 Shots for Neuropathy People with severe B12 deficiency or trouble absorbing it orally are best suited for B12 injections

doi: 10.1152/physiolgenomics.00194.2006