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In our study, FOXO4-DRI was found to effectively promote apoptosis in senescent cells by blocking the FOXO4-P53 interaction and facilitating P53 phosphorylation

Regulation of ferroptosis-related pathways or protein expression, intracellular ROS levels, and the homeostasis of various metabolic pathways can affect the sensitivity of cells to ferroptosis, thereby inducing ferroptosis

The predominance of observational designs and the presence of residual confounding further increase heterogeneity

In further embodiments, R 1 is methyl

This GSH depletion has a dual effect: it triggers oxidative stress within the cell, thereby stabilizing and activating NRF2

Rather than waiting for deficiency symptoms to appear and then supplementing reactively, the pyridoxine built into each injection provides ongoing replenishment