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6.3 Insufficient human trial data Although experimental research shows the potential of plant-derived nanoparticles in addressing diabetes and male infertility, verification from human trials remains limited (319)

For instance, while topical agents may suffice for localized mild disease, systemic therapies are often warranted for extensive or refractory cases (Rendon & Schakel 2019)

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They demonstrated that pretreatment of cultured SOD1 G93A astrocytes with MitoQ was able to reduce the formation of superoxide and peroxynitrite radicals, protect motor neurons against oxidative damage and improve the ability of mitochondria to generate ATP (Cassina et al., G93A mouse model, treatment with MitoQ at the onset of disease also delayed the decline of mitochondrial function in the spinal cord, protected against motor neuron loss and astrogliosis in the spinal cord

Recent studies identify a mechanistic link between a Western diet, gut microbiotadependent metabolism, and development of both cardiovascular disease (CVD) and metabolic diseases (13)