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The most common is simply that the drops do not work

Symptoms of B12 deficiency include: Low energy and fatigue Digestive problems Depression and moodiness Insomnia Brain fog and memory loss Anemia Reduced immune system function Tingling or numbness in the extremities Swollen tongue Loss of vision or hearing Jaundice Kidney disease Pale skin Poor circulation in the extremities If you are over age 50 and are experiencing one or more of the above symptoms, boosting your intake of B12 cannot hurt, and it may provide a safe and inexpensive solution while preventing a wrong diagnosis

How to check for Vitamin B12 deficiency with lab tests: Serum Vitamin B12 levels: should be in the top 75% percentile of the lab reference range (yes even mid-range can still be too low)

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Both dorsogluteal and ventrogluteal sites are commonly referenced in clinical practice, but they differ significantly in anatomy, safety, and recommended use

Oceanologica Acta 9 , 6572 (1986)