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10.1073/pnas.0603704103 273 YangW.BarthR

PubMed , European Journal of Epidemiology , vol

In brief, the first and rate-limiting step is the abstraction of a hydrogen atom by non-heme ferric iron (Fe(III)), involving a proton-coupled electron transfer in which the electron is transferred directly to the iron and the proton is acquired simultaneously by the hydroxide ligand in a concerted mechanism to give a substrate radical, while the iron atom is reduced to the ferrous state (Fe(II))

9 (6), 360370 (2012) S.N

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For example, the review mentioned one study suggesting creatine may increase manic or hypomanic episodes in people with bipolar disorder and another linking just a week of 25 grams (g) daily supplements to increased nervousness and aggression in 2 out of 10 study participants