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Liver-expressed antimicrobial peptide 2 (LEAP-2), the endogenous noncompetitive allosteric antagonist of the growth hormone secretagogue receptor 1a (GHSR1a), was recently identified as a key endocrine factor regulating systemic energy metabolism

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DISCUSSION By combining previous models and making a few parameter changes, we have created a new model of glutathione metabolism that we have used to investigate sexual dimorphism in the glutathione pathway in the liver

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