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Table 3 Integrative framework of pathology, biomarkers and the therapeutic interventions

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Participants took two capsules daily for 9 months, providing either 10 milligrams of silicon per day as choline-stabilized orthosilicic acid (ch-OSA) or a placebo

Lancet 349 (9045): 113117

Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress

Third, GSNO interacts with E3 ubiquitin ligase C-terminus Hsc70 interacting protein (CHIP), inhibiting CHIP-CFTR interaction and reducing CFTR ubiquitination, which increases both mature and immature F508del-CFTR levels and enhances cell surface expression (Zaman et al., 2019)