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summary Folic acid supplements are a practical way to boost folate levels during pregnancy, but excessive doses may increase insulin resistance and negatively affect brain development in children

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10.1016/j.nutres.2023.10.003 150 ZhangP

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Cycling protocols812 weeks on, 4 weeks offmay preserve receptor sensitivity, though published trials havent demonstrated reduced efficacy within standard research durations

Yes B12 is watersoluble, and excess amounts are excreted naturally