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This receptor-mediated action adds a second layer of immune modulation on top of the direct NF-kB suppression

The ideal model of 5-OP accumulation would have been one where the 5-OP was generated endogenously

However, there is good evidence that, although folic acid binds avidly to this receptor in the choroid plexus, it does not cross the opposite, apical membrane to enter the cerebrospinal fluid (CSF) (78)

Several studies have supported the role of pro-inflammatory mediators released from visceral adipose tissue (VAT) in the progression of NAFLD (202, 203)