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Coron Artery Dis 26(2):176183 Rights and permissions About this article Cite this article Luft, F.C

W., Zhang Q

HCAR1-mediated lactate effects have been suggested to be neuroprotective in depression (Tang et al., 2014

[DOI] [PubMed] [Google Scholar] 138.Nemeth E, Tuttle MS, Powelson J, et al

However, for both monotherapy of MEK inhibitor and combined treatment of BRAF and MEK inhibitors, acquired resistance through reactivation of the MAPK pathway can restrict their therapeutic efficacy (141)

Various factors, such as skin aging, inflammation, sunlight exposure, wound healing, and fibrosis, can promote ECM remodeling, potentially resulting in aberrant ECM modifications (Pfisterer et al, 2021), which may modify the presentation of ECM ligands and alter substrate stiffness