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Key readout endpoints include serum ALT and AST enzyme release (hepatocyte membrane integrity), hepatic malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) as lipid peroxidation markers, H&E-stained hepatic necrosis area scoring (zones IIII centrilobular pattern), TUNEL-positive hepatocyte apoptosis count, and MPO activity as a proxy for neutrophil infiltration

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N-acetyl cysteine was able to prevent acute kidney injury (acute renal failure) as documented by reduced biomarkers of oxidative stress and inflammation and increased antioxidant biomarkers (Ozturk et al

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10.1016/B978-0-12-407697-6.00002-7 135