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Rotate injection sites with each dose to prevent tissue changes that can affect absorption

68-70 There are few other studies in humans assessing this effect

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[20] Toxigenic culture, in which organisms are cultured on selective media and tested for toxin production, remains the gold standard and is the most sensitive and specific test, although it is slow and labor-intensive

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However, in a meta-analysis which included case-control studies and cohort studies as well as RCTs, plaque size and pain but not curvature were significantly improved using ESWT [77]