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Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover

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This deficiency leads to the premature destruction of these cells, resulting in anemia

Although in the normal adult human brain the level of 3R-tau is similar to that of 4R-tau, immunocytochemistry and biochemical analysis indicate that the ratio of 3R- to 4R-tau is altered in AD and other neurodegenerative disorders (191)

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