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Lay Summary for Documentation Neuropathy is damage or disease affecting the nerves outside the brain and spinal cord

To confirm these findings in a different species for translational relevance, we found that HSL inhibition similarly reduced efferocytosis in murine M2 bone marrow-derived macrophages (BMDMs) (Fig

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one or more NNMT inhibitors such as a cation of Formula I or IA, or otherwise disclosed herein one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy