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29 It involves the direct intratumoral administration of immunostimulatory immunoadjuvants such as pattern recognition receptor (PRR) agonists, including toll-like receptor (TLR) agonists, STING agonists, cytokines, or oncolytic viruses, either alone or in combination with ICD inducers, including chemotherapy, radiotherapy, photodynamic therapy (PDT), or nanomaterial-based platforms, 30,31,32 thereby enabling rapid, localized immune activation (Fig

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