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FIGURE 1 Glutathione S -transferase P1 is also involved in cell death regulation, interacting with apoptotic signaling pathways as for example c-Jun NH2-terminal kinase (JNK1), ERK1/ERK2, or tumor necrosis factor receptor-associated factor 2 (TRAF2

Among them, chemokines play a crucial role in recruiting immune cells, pro-inflammatory cytokines coordinate the activation of immune cells, anti-inflammatory cytokines participate in local immune regulation, pro-survival cytokines assist in the survival and differentiation of immune cells, and damage-associated molecular patterns act as a bridge between innate and adaptive immunity

Lactoferrin reduces methotrexate-induced small intestinal damage, possibly through inhibition of GLP-2-mediated epithelial cell proliferation

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