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On the one side, p53 promotes the expression of SAT1 (Qiu et al., 2020), and then increased SAT1 cooperates with ROS to lead to lipid peroxidation (Murphy 2016), further oxidizes PUFAs, and finally causes ferroptosis

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[DOI] [PMC free article] [PubMed] [Google Scholar] 110.Suwannapan U., Chatpongtada S

doi: 10.1186/s12967-022-03566-6

plantarum CAI6 may prevent cardiovascular disease in hyperlipidemic mice by Nrf2-induced anti-oxidative defense and regulation of lipid metabolism [53]