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The complex interplay between immune suppression and activation, elevated peripheral pro-inflammatory cytokines and other inflammatory markers, and cytokine involvement in neurophysiology suggests that inflammation is a key pathological mechanism underlying depression (7376)

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According to the leaky gut theory, these alterations in gut microbiota may be related to inadequate perfusion to the viscera due to cardiac congestion or impaired ejection capacity in patients with HF, and ischemic edema in the intestine caused by ischemia, which might increase the permeability of the intestinal epithelium (Sandek et al., 2007), thus allowing intestinal macrobiotic and bacterial metabolites to gain access to the circulatory system through the compromised barrier

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However, most NO donors exhibit low blood retention and low tumor accumulation, which may be the reason for their lack of therapeutic efficacy (11)

Oncolytics 17 , 518530 (2020)