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Acknowledgments We would like to acknowledge the reviewers for their helpful comments on this study

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Mitophagy generally consists of two steps: the initiation of general autophagy and the priming of damaged mitochondria for autophagic recognition (Figure 2)

The superfamily of human soluble GSTs is further divided into eight separate classes: Alpha (A1A4), Kappa (K1), Mu (M1M5), Pi (P1), Sigma (S1), Theta (T1T2), Zeta (Z1) and Omega (O1O2) (Hayes et al., 2005)

Dr Lonsdale, who passed away at the age of 100, dedicated nearly five decades to exploring how high-calorie malnutritiona state resulting from diets rich in processed foods but deficient in essential micronutrientsimpairs metabolism and contributes to chronic health conditions

In addition to direct lipolytic potential, Frag 176-191 might indirectly support energy expenditure, possibly through potential modulation of 3-adrenergic receptor (3-AR) expression