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We speculate that the combined toxicity of the two drugs may lead to intracellular ROS levels far exceeding those caused by a single drug, resulting in rapid depletion of glutathione (GSH), triggering hepatocyte apoptosis/necrosis and red blood cell hemolysis

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We notice that by increasing the amount of (CENP-A/H4) 2 relative to DNA, we enrich the faster traveling particle, so we concluded that the particle corresponding to the slower band on gel is a tetrasome, whereas the one that travels faster and almost the same as the CENP-A nucleosome is the 2x(CENP-A/H4) 2 octasome (Fig S1A and C)

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