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2022;5: e1233

Cons: The primary argument against it is dilution

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The primary efficacy variable was the percent change of BMD at 24 Months relative to baseline

Its toxic effects extend to male reproductive health, where it adversely effects on testicular function, impairs spermatogenesis, and induces oxidative stress through mechanisms such as elevating the Reactive oxygen species concentration, mitochondrial dysfunction, and cellular apoptosis which severely affects the reproductive health (74, 75)

Adrenal hormonal imbalance-associated oxidative stress Antioxidants combat oxidative stress Both endogenous and exogenous antioxidants help combat oxidative stress in the body