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Early after cuprizone initiation and in the context of minimal inflammation, changes in myelin composition and/or lipid polarity have been detected well in advance of oligodendrocyte cell body damage giving weight to the idea that cuprizone may have direct, albeit subtle, effects on myelin [79, 98, 99] the human relevance of such altered myelin biochemistry prior to overt demyelination has since been confirmed [98]

placebo at week 72 (95.3% vs

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Abstract Irisin, an exercise-induced myokine with promising therapeutic potential, exhibits neuroprotective effects in Parkinsons disease (PD)

In this study, the expression levels of MAP7D1 were significantly decreased in the kidney tissue of rats exposed to the high concentration of TAA compared to the control group