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In November 2023, the USA FDA banned compounding pharmacies from selling a number of peptides

doi: 10.1002/pds.70138 154 ChuPYEdmondsonEKFloryJHHuangJHennessyS

The specific mechanism of editing is idiosyncratic to each synthetase but in general, once formed the aa-tRNA triggers a conformational change and the 3 terminus containing the aa is translocated from the active site to the editing site, sometimes traversing distances as large as 40 (Silvian et al