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Our findings also suggested the induction of necroptosis during ferroptosis in erastin-treated acute monocytic leukemia THP-1 cell lines after treatment with an inhibitor of N-myristoyltransferase IMP-366

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The hGAN-G332R mice showed complete gigaxonin loss compared to hGAN and wild-type C57BL/6 control mice, similar to GAN patient neurons with the G332R mutation

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As the N-terminal protein sequence of SMT15 extended to 46 amino acids, the SMT15 N46 :eYFP protein was found to target to the chloroplast (Figure 2B), indicating that the first 46 aa of SMT15 is sufficient to guide the protein into the chloroplast

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