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Nrf2 predominantly governs antioxidant defenses by neutralizing ROS, whereas FXR plays a key role in maintaining bile acid balance and mitigating bile acid-driven oxidative stress [147]

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a drop in the AMP:ATP and ADP:ATP ratios indicates low energy availability and triggers AMPK activation

The administration of 5-FU resulted in necrotic enteritis in the form of necrosis of the apical portion of the intestinal mucosa and degeneration of the basal intestinal glands (Fig