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Astrocytes react to A-induced stress by dynamically modulating their autophagy machinery to enhance the clearance of A oligomers

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The first and rate-limiting step is catalyzed by the enzyme glutamate-cysteine ligase (GCL), which fuses glutamate and cysteine

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The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy

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