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doi: 10.1038/s41596-019-0236-5 92 AkbarAMalekianFBaghbanNKodamSPUllahM

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PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage

Therefore, future clinical translation will probably benefit from biomarker-guided frameworks, incorporating (1) FSP1 abundance/localization, (2) CoQ pool size and redox state, (3) lipid peroxidation signatures and (4) metabolic context (mitochondrial activity and sulfur/selenium flux)