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Initially thought to be constitutively expressed, NOS3 is now recognized to be highly responsive to various regulatory stimuli, which adjust its transcription to match the vascular environments needs (Mattsson et al., 1997

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They also note that the pharmacological action sites of antidepressants may not fully correspond to the neurobiological regions implicated in depressive pathology

Beyond SCFAs, other microbial metabolites affect brain metabolism and vascular function

doi: 10.1016/S0946-672X(96)80036-8 38