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At the same time, compared to HCs, the levels of a wide range of metabolites such as glutamine, asparagine, N-Formimino-glutamate, putrescine, serotonin, kynurenine, 2-Aminomuconate, Cys-Gly, 5-Aminolevulinate, and pyridoxine were reduced in the plasma of R group ( Figure 5C , Supplementary Figure 4A )

10.1016/j.jchromb.2007.03.010 207 YinH.ZhouY.WenC.ZhouC.ZhangW.HuX.et al (2014)

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These mechanisms may be conditionally expressed in a process termed acclimation