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Effects of dietary chemopreventive phytochemicals on P-glycoprotein function

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In the first step, NADPH reduces flavin partition, then flavin is oxidized and a redox-active disulfide bridge is reduced, thereby producing a thiolate anion and a cysteine

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Functional validation confirms SLC7A11 as a direct miR-152-3p target whose overexpression rescues methionine dependency in SNHG3-deficient PCa cells, establishing the SNHG3/miR-152-3p/SLC7A11 regulatory axis ( Figure 1 )

doi: 10.1016/j.lfs.2024.122863 11 BaoM.ZhangP.GuoS.ZouJ.JiJ.DingX.et al