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Glutamate excitotoxicity can lead to increased production of neuronal nitrogen oxide synthase (nNOS) which in turn can lead to higher production of reactive nitrogen species, damage to cellular components, and ultimately, cell death (Sullivan and Brown, 2005), and this is thought to be mediated by the oxidative stress triggered by excitotoxicity (Nguyen et al., 2011)

Aksoy F, Dogan R, Ozturan O, Eren SB, Veyseller B, Pektas A, et al

10.1016/0006-8993(71)90439-2 Brain Res

Effect of nuclear actin on endothelial nitric oxide synthase expression

Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complexmediated inflammation in mice

Increases in transaminases occurred in two subjects highlighting the fact that blood chemistry should be performed even when individuals are taking over-the-counter supplements