glutathione peroxidase 1 pathway Frontiers Glutathione Peroxidases: An Emerging and

Key mitochondrial and antioxidant molecules such as Cytochrome c, UCH-L1, and thioredoxin domain-containing protein 12 were significantly downregulated

Independently of its function in the -secretase complex, PSEN1 itself is required for complete lysosomal acidification 108,117,118

Retrieved from : 187 San MartnA.DuP.DikalovaA.LassgueB.AlemanM.GngoraM

To address these limitations, future research should prioritize: (1) developing more physiologically relevant preclinical models (e.g., humanized liver chimeras, diet-induced murine models with metabolic comorbidities) to better recapitulate human NAFLD pathophysiology

The lack of robust clinical evidence limits their use in clinical practice

AlqradMAIEl-AgamyDSIbrahimSRMSirwiAAbdallahHMAbdel-SattarEet al