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10.1016/j.pbb.2021.173205 88

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reported that elevated TNF- and IL-6 levels promote osteoclast differentiation and activation while inhibiting osteoblast function [5556], which aligns with our experimental observations

Given that the phenotype is highly variable, it is likely that residual TPK1 activity and/or other cellular kinases (albeit at a lower extent and favored by the mass action of high thiamine doses) may also phosphorylate thiamine, thereby partly circumventing the metabolic block

GSH degradation has been believed to occur primarily in the extracellular space

The development of individualized rehabilitation exercise strategies for patients with coexisting COPD and sarcopenia may be beneficial for their functional maintenance