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Furthermore, apart from the established impact of cutaneous irAEs on OS of melanoma patients, gastrointestinal irAEs, especially diarrhoea, which usually limits ICI treatment, was paradoxically associated with improved OS and PFS in metastatic melanoma patients (HR 0.56

Gastroenterology 118 , 163172 (2000)

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There was an increase in respondents who felt they understood their condition somewhat or better than before after visiting a specialist

10.1016/j.fct.2009.09.018 19 GyngysiM.WinklerJ.RamosI.DoQ

24 Fasting may also delay senescence by suppressing genes that trigger the production of zombie cells