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Genotoxic, biochemical and histopathological studies to assessment the topiramate hepatorenal toxicity in mice

Previous kinetic studies have shown that selenium-containing Gpxs, the predominant form in vertebrates, do not follow saturation kinetics and consequently have infinite Michaelis Menten kinetic parameters (Km and kcat) (Toppo et al., 2009)

Advancements in modern medicine have revealed many unkown medicinal properties of turmeric which include anti-oxidant, anti-mutagenic, anti-cancer, anti-microbial and anti-cardiovascular activities [7-3]

Additionally, natural fermentation techniques are being adopted to produce vegan, non-GMO, and allergen-free formulations

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By highlighting underexplored mechanistic connections between gut dysbiosis and -syn biology, this review underscores the potential of microbiome-targeted strategies for early diagnosis and disease modification