As NAD+ levels drop with age, our cells become more vulnerable to damage
For final OCR values after each titration, the OCR was calculated by taking the average value from the chamber with Amplex UltraRed and the chamber with TMRM for each sample

Disclosures: Jun Tsuchiya: Nothing to Disclose, Masato Miyoshi: Nothing to Disclose, Sei Kakinuma: Nothing to Disclose, Taro Shimizu: Nothing to Disclose, Keiya Watakabe: Nothing to Disclose, Tomohiro Mochida: Nothing to Disclose, Kento Inada: Nothing to Disclose, Shun Kaneko: Nothing to Disclose, Fukiko Kawai-Kitahata: Nothing to Disclose, Sayuri Nitta: Nothing to Disclose, Miyako Murakawa: Nothing to Disclose, Mina Nakagawa: Nothing to Disclose, Yasuhiro Asahina: Nothing to Disclose, Ryuichi Okamoto: Nothing to Disclose 1807 METTL3-MEDIATED M6A MODIFICATION REGULATES THE POLYCOMB REPRESSIVE COMPLEX 1 (PRC1) COMPONENTS BMI1 AND RNF2 IN HEPATOCELLULAR CARCINOMA CELLS Weina Chen Jinqiang Zhang 1 Wenbo Ma 1 Nianli Liu 1 Tong Wu 1 , 1 Tulane University Background: Methyltransferase- like 3 (METTL3) is a primary RNA methyltransferase that catalyzes N6-methyladenosine (m6A) modification which is implicated in several human cancers including hepatocellular carcinoma (HCC), although its mechanism of action remains to be further defined

Investigation, Z.Z., Q.X., X.C., L.W., J.W
It also plays a role in reducing muscle wasting and supporting tissue repair, which are important during aging or recovery
Due to the lack of clinical studies on some drugs, the efficacy of ferroptosis inhibitors in a clinical setting remains undetermined