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10.1016/j.neuron.2013.10.025 Neuron 68 HussainN

Additionally, differences between cerebrospinal fluid and fecal lactate levels suggest an incomplete understanding of intestinal lactate metabolisms impact on ME/CFS patients [25, 44, 49]

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You need to see a doctor immediately if you have one of the following symptoms: Your knee is swollen or red Your pain is getting worse or is very sharp Your pain prevents you from doing everyday activities You have a locking sensation in your knee Your knee feels unstable Youre still not sure

The concept is that patients could achieve significant weight loss on higher doses and then step down to 4mg to maintain results with fewer side effects