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The paw volume was measured on 3rd, 6th, 9th, 12th, 15th, 18th and 21st days (Fig

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The Fh8 presents two EF-hand motifs, and it was characterized as a Ca 2+ sensor protein : when calcium binds, the Fh8 switches from a closed (apo-state) to an open (calcium-loaded state) conformation due to the reorientation of the four helices, exposing a large hydrophobic region that acts as a target-binding surface (Fraga et al., 2010)

This reaction is dependent on a co-factor known as thiamine pyrophosphate

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Smart biomaterials for aged bone repair and regeneration will demonstrate significant promise and benefits with further development and precise clinical translation