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B12-downregulated genes in this group were related to positive regulation of transcription by RNA polymerase II, processing and transport of mRNA, mRNA splicing, cellular response to DNA damage stimulus, activation of innate immune response, positive regulation of IL-6 and IL-2 production, T-cell differentiation in thymus, histone modification, viral transcription and DNA conformational change

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Details were discussed with each patient in advance with emergency hospital backup facilities available

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Moreover, the comparison of CRP levels at the different timepoints evaluated did not show any significant differences between the LCLT and placebo groups, as presented in Table 3

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