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As part of the innate immune response, complement system dysregulation is implicated in AMD pathogenesis, with zinc able to bind CFH and other complement proteins to modulate inflammatory responses [437, 438]

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In a DMBA/TPA two-stage skin carcinogenesis model, overexpression of the skin antioxidant enzymes Gsh-px or Gsh-Px + SOD increases cancer instead of decreasing it [103]