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In combined B12 and folate deficiency, B12 replacement must be started before folate supplementation to avoid precipitating or worsening neurological damage

Thus, intranasal formulations should be carefully balanced with safety considerations and clinical success, rather than relying heavily on permeation enhancers to achieve effective, well-tolerated therapy (Qiu et al., 2025)

A final volume of 6 l click reaction mixture was added per 100 l lysate and shaken for 1 h at room temperature before quenching with 5 mM EDTA

That moment captured something Im seeing more often

D-HH: Funding acquisition, Writing review & editing, Writing original draft

This approach captures the broader diagnostic categories (e.g., E11.1 was reduced to E11), ensuring that key information is retained without overcomplicating the model with finer diagnostic subcategories that may add redundancy or noise to the data