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Psoriasis: a mixed autoimmune and autoinflammatory disease

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A prospective clinical study has demonstrated that ferroptosis levels showed considerable promise as a novel monitoring indicator and therapeutic target, as they play a critical role in predicting the healing rate of DFUs and assisting clinical treatment decisions [24]

Reactive oxygen species (ROS) activate intracellular signaling cascades that stimulate pro-inflammatory gene expression, while activated immune cells further generate ROS and inflammatory mediators (e.g., cytokines, chemokines), amplifying tissue injury at inflammatory sites [116]