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Targeting the reduction of NETs thus warrants investigation as a potential therapeutic strategy

Hypoxia induces radioresistance, epithelialmesenchymal transition, cancer stem celllike phenotype and changes in genes possessing multiple biological functions in head and neck squamous cell carcinoma

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For instance, differentiation of OL lineage cells generated from MS patient iPSCs occurs efficiently in vitro and in vivo 168 , yet is inhibited by exposure to peripheral blood mononuclear cell supernatants, with CD4+ T cell-derived interferon (IFN)- being a prime contributor 169