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References 1 New England Journal of Medicine REDEFINE 1Garvey WT et al

The mechanistic hypothesis: Semaglutide activates GLP-1R, appetite suppression, glycemic control Cagrilintide activates amylin receptors, appetite suppression via the area postrema, slowing of gastric evacuation Two independent mechanisms of appetite suppression a supra-additive effect In Phase 1b and Phase 2 trials the combination showed a stronger effect than either component alone : Semaglutide alone: 14.9 % (STEP-1) Cagrilintide alone (Phase 2): 10.8 % CagriSema combination (Phase 2): 15.6 % CagriSema Phase 3 (REDEFINE 1): 25.3 % CagriSema thus becomes the largest body-weight signal reported in the published incretin literature to date , stronger than Tirzepatide (22.5 % in SURMOUNT-1) and comparable to Retatrutide

Tumor exosomes could also facilitate organ-specific metastatic behavior by preparing pre-metastatic niches [19, 21]

On the first day, every peptide put to a vote all four of them received a favorable recommendation , including BPC-157 (8 yes, 6 no, 1 abstention) and KPV

10.1007/s00441-019-03016-8 42 HendriksT.MastboomW

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