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The combination with semaglutide targets both reward-driven eating behaviors and energy balance homeostasis, which may explain the additive weight loss observed with CagriSema beyond what either agent achieves alone

Both reported pain relief and no adverse effects, but these studies are far too limited to draw conclusions about efficacy or safety in humans7

[1] Retatrutide: What the Evidence Actually Shows Retatrutides pivotal obesity dataset is a Phase 2, double-blind, randomised, placebo-controlled trial in adults with obesity (or overweight plus a weight-related condition), testing once-weekly doses up to 12 mg over 48 weeks