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SKU: 13900403984
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However, the most striking transcriptional reconfiguration was observed in gsh strain, where 483 genes exhibited altered expression patterns, reflecting a substantial shift that differs from WT strain

Specifically, compounds 1012, 17, 2836, 42 , and 48 (IC 50 : 25.45 nM 61.25 nM) exhibited greater effectiveness against BChE than donepezil and tacrine (IC 50 : 63.00 nM, 94.13 nM)

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Given its pivotal role in the regulation of multiple cellular processes, this review systematically summarizes three major therapeutic strategies for Nrf2 activation: clinical and preclinical small-molecule agents with DMF and CDDO-Im as representative examples